STRIDE was initially developed for UNIX and ported to MSDOS using the freely available DJGPP compiler which is a port of the GNU C compiler to MSDOS by DJ Delorie. I tested STRIDE for DOS on hundreds of PDB files using a 486DX2 PC with 8mB of memory and another one with 16 mB. In general it runs without problems, but for VERY large PDB files 16 mB of memory are strongly recommended. Dmitrij Frishman European Molecular Biology Laboratory Meyerhofstr. 1, 69012 Heidelberg, Germany tel. +49 -6221 - 387231 fax. +49 -6221 - 387517 frishman@embl-heidelberg.de